Mechanical characterization of skeletal muscle myofibrils
نویسندگان
چکیده
منابع مشابه
The adenosinetriphosphatase activity of myofibrils isolated from skeletal muscle.
Muscle has long been known as a source ofmany well characterized enzymes and proteins, but information about the localization of these substances within the cell is obtained mainly by inference and other indirect means. Direct investigation of the structural interrelationships of such constituents of muscle, most of which have been intensively studied in the purified form, should reveal conside...
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Although many studies have dealt with the mechanism of muscular contraction and with the composition and structure of myofibrillar proteins, very little information exists as to the origin of these substances, or the manner in which they are assembled. Moscona (l), from the study of myogenic cells of the chick embryo, found indications that cytoplasmic granules may be the precursors of myofibri...
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In pigeon breast muscle the mitochondria are the principal site of oxidative metabolism, whereas the myofibrils are incapable of oxidizing intermediates of the Krebs cycle. The mitochondria contain the oxidative enzymes, and the sarcosomes are associated with a factor which accelerates the mitochondrial oxidative rate. The maintenance of myofibrillar contractility and structure is closely corre...
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To assess the in vivo effects of therapeutic interventions for the treatment of muscle disease, quantitative methods are needed that measure force generation and fatigability in treated muscle. We describe a detailed approach to evaluating myo-mechanical properties in freshly explanted hindlimb muscle from the mouse. We describe the atraumatic harvest of mouse extensor digitorum longus muscle, ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1996
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(96)79470-5